A neural network for predicting the stability of RNA/DNA hybrid duplexes

作者：Ma, LX; Cheng, CM^*; Liu, XH; Zhao, YF; Wang, AL; Herdewijn, P

来源：Chemometrics and Intelligent Laboratory Systems, 2004, 70(2): 123-128.

DOI：10.1016/j.chemolab.2003.10.002

A back propagation (BP) neural network (NN) method has been developed to predict the stability of RNA/DNA duplex. Calculated T-m of hybrid formation with the present parameters fits the experimental values within reasonable errors (AD = 1.2887 K, SEP = 1.782, R-2 = 0.9673 for NN1; AD = 2.1388 K, SEP = 3.506, R-2 = 0.8889 for NN2). And it has the advantage that the determinations of thermodynamic parameters (TP) are not needed.

• 出版日期2004-2-28
• 单位河北医科大学; 上海电力大学; 清华大学; 上海交通大学