Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression

作者：Ballarin Jose; Arce Yolanda; Torra Balcells Roser; Diaz Encarnacion Montserrat; Manzarbeitia Felix; Ortiz Alberto; Egido Jesus; Antonio Moreno Juan

来源：Nephrology Dialysis Transplantation, 2011, 26(10): 3408-3411.

DOI：10.1093/ndt/gfr391

• CD163
• haemosiderin
• macrophages
• paroxysmal nocturnal haemoglobinuria

Decreased renal function has been observed in diseases with intravascular haemolysis, including paroxysmal nocturnal haemoglobinuria (PNH). However, the mechanisms via which haemoglobin enhances renal damage in this pathology are not fully known. We report a case of acute renal failure associated to PNH and extensive haemosiderin deposits in tubular cells. Renal biopsy also revealed a strong immunostaining of CD163 (a haemoglobin scavenger receptor expressed in macrophages) and oxidative stress markers (NADPH-p22 phox and haeme oxigenase-1) in areas with deposits of iron. This fact provides evidence for a pathogenic role for free haemoglobin in tubulointerstitial renal injury in human PNH disease.

• 出版日期2011-10