A benchmark study on 883 nasopharyngeal cancer patients treated in two Italian Centres from 1977 to 2000. Part I: evolving technical choices and survival

作者：Tonoli S; Magrini S M; Costa L^*; Paiar F; Simontacchi G; Scotti V; Pasinetti N; Barca R; Barbieri D; De Stefani A; Cellai E; Buglione M; Biti G

来源：Radiologia Medica, 2012, 117(4): 690-714.

DOI：10.1007/s11547-011-0755-9

• Nasopharyngeal cancer
• Radiotherapy
• Treatment techniques
• Survival
• Patterns of care

The authors sought to define treatment results according to the different accrual periods and clinical-therapeutic features in a large series of nasopharyngeal cancer (NPC) patients treated in two Italian centres over more than two decades. %26lt;br%26gt;A total of 883 patients consecutively treated with radiotherapy between 1977 and 2000 at the Florence (FLO) and Brescia (IRA) Radiation Oncology centres were studied. Five-year overall (OS) and disease-specific (DSS) actuarial survival rates in the different pathological, clinical and therapeutic subgroups were calculated, along with the actuarial local-regional control (LRC) probability. %26lt;br%26gt;At univariate analysis, survival and local control rates were significantly better in the more recent accrual periods and in the more favourable disease presentations; treatment-related parameters mainly affect LRC. At multivariate analysis, patient- and disease-related factors had a more evident prognostic effect than did therapeutic factors, although dose to the nasopharynx and treatment technique had a marginally significant impact on DSS and OS. %26lt;br%26gt;Results of this benchmark study may be useful for understanding the development of new radio-therapy techniques for NPC, such as three-dimensional conformal radiotherapy (3D-CRT) and particularly intensity-modulated radiotherapy (IMRT).

• 出版日期2012-6