The investigation of lithium formate hydrate, sodium dithionate and N-methyl taurine as clinical EPR dosimeters

作者：Lelie S^*; Hole E O; Duchateau M; Schroeyers W; Schreurs S; Verellen D

来源：Radiation Measurements, 2013, 59: 218-224.

DOI：10.1016/j.radmeas.2013.07.001

• Lithium formate
• EPR
• Radiation dosimetry
• Radiotherapy

Introduction: EPR-dosimetry using L-alpha-alanine is an established method for measuring high doses of ionizing radiation. However, since a minimum dose of approximately 4 Gy is required to achieve sufficient low uncertainties (1-2%) for clinical application, alternative dosimeter materials are being inquired. Lithium formate (LiFo) monohydrate has been studied by several groups and has revealed several promising properties in the low dose region (%26lt;4 Gy). The fading properties, however, are somewhat unpredictable, and depend on properties not yet fully uncovered. This paper reports the results from a study of lithium formate hydrate and N-methyl taurine as potential low dose EPR dosimeters. %26lt;br%26gt;Methods and materials: Pellet shaped dosimeters of lithium formate monohydrate, lithium formate hydrate, sodium dithionate and N-methyl taurine were produced using a manual Weber press, L-alpha-alanine was obtained from Harwell dosimeters and irradiated using 60 kV and 6 MV X-ray beams, and Co-60 gamma-rays to a dose of 30 Gy and dose ranges of 0.5-100 Gy and 2-20 Gy respectively. The dosimeters were measured using an Electron Paramagnetic Resonance (EPR)-spectrometer. The detector responses for 6 MV and Co-60 radiation beams, the fading behaviors and signal shape in time were investigated. %26lt;br%26gt;Results: Lithium formate monohydrate and lithium formate hydrate are apparently associated with near identical EPR-spectra (mainly one broad line), and the same spectrum arises for all radiation energies investigated. The shape of the EPR resonance remains constant with time, but the intensities decreases, and the fading is more prominent for the monohydrate than for the hydrate. The EPR resonance associated with N-methyl taurine is more complex than the resonance associated with LiFo and it changes with time, implying radical transitions and growth. %26lt;br%26gt;Conclusions: The study showed that lithium formate hydrate is a strong candidate for EPR dosimetry with slightly better fading characteristics compared to lithium formate monohydrate.

• 出版日期2013-12