Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

作者：Ishiuchi Kan'ichiro; Kubota Takaaki; Ishiyama Haruaki; Hayashi Shigeki; Shibata Toshiro; Mori Koichiro; Obara Yutaro; Nakahata Norimichi; Kobayashi Jun'ichi^*

来源：Bioorganic & Medicinal Chemistry, 2011, 19(2): 749-753.

DOI：10.1016/j.bmc.2010.12.025

• Lycopodium alkaloids
• Lycopodium complanatum
• Lyconadin D
• Lyconadin E
• Complanadine E

Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.

• 出版日期2011-1-15