APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease

作者：Zhou, Qin; Peng, Dantao; Yuan, Xinrui; Lv, Zeping; Pang, Shenghang; Jiang, Wenyu; Yang, Chuyu; Shi, Xiaohong; Pang, Guofang; Yang, Yige; Xie, Haiqun; Zhang, Wandong; Hu, Caiyou^*; Yang, Ze

来源：Neural Regeneration Research, 2014, 9(6): 653-660.

DOI：10.4103/1673-5374.130117

• nerve degeneration
• cognitive disorders
• dementia
• Alzheimer's disease
• polymorphism
• apolipoprotein E
• apolipoprotein CI
• low density lipoprotein receptor-related protein
• NSFC grant
• neural regeneration

Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE epsilon 4 carriers compared with non-carriers. In addition, the APOE e4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE epsilon 4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease.

• 出版日期2014-3
• 单位广西壮族自治区江滨医院; 北京医院