Acute Effects of Cigarillo Smoking

作者：Blank Melissa D^*; Nasim Aashir; Hart Alton Jr; Eissenberg Thomas

来源：Nicotine & Tobacco Research, 2011, 13(9): 874-879.

DOI：10.1093/ntr/ntr070

Introduction: Cigarillo smoking likely exposes users to many of the same toxicants (e.g., nicotine, carbon monoxide [ CO]) as cigarette smoking. Yet, few controlled clinical laboratory studies evaluating of the effects of cigarillos exist. This study evaluated the cardiovascular response, toxicant exposure, subjective effects, and puffing topography of a popular cigarillo brand, Black & Mild (B&M).
Methods: Sixteen B&M smokers (M +/- SD = 1.9 +/- 2.5 cigarillos/day for 3.4 +/- 3.5 years) participated in 2 counterbalanced conditions: lit (ACTIVE) or unlit (SHAM) B&M in which they completed two 10-puff smoking bouts (30-s interpuff intervals).
Results: Plasma nicotine concentrations for ACTIVE increased significantly from pre-smoking (M +/- SEM = 2.0 +/- 0.0 ng/ml) to 5 min after Bouts 1 (5.3 +/- 0.8 ng/ml) and 2 (4.9 +/- 0.9 ng/ml) but did not increase above 2.0 +/- 0.0 ng/ml at any timepoint for SHAM. Heart rate increased significantly from pre- to post-smoking for ACTIVE but not for SHAM. Average expired-air CO levels, collapsed across time, were 14.3 +/- 0.8 ppm for ACTIVE and 4.5 +/- 0.2 ppm for SHAM. Neither condition reduced symptoms of nicotine/tobacco abstinence reliably, although ratings for some measures were significantly lower for ACTIVE than for SHAM. ACTIVE, but not SHAM, produced a variety of positive effects related to product sensory characteristics (e.g., "satisfying," "pleasant"). Smoking topography did not differ across the two conditions.
Conclusions: Ten puffs from a B&M cigarillo deliver active doses of nicotine and considerable amounts of CO but do not suppress abstinence-induced withdrawal symptoms reliably. The nicotine delivery profile suggests that cigarillo smoking may promote nicotine/tobacco dependence and the CO exposure likely poses significant health risks.

• 出版日期2011-9