An Efficient and Clean Synthesis of Pyrido[2,3-d]pyrimidine-4,7-dione Derivatives in Aqueous Media

作者:Shi Da Qing*; Shi Jing Wen; Rong Shao Feng
来源:Journal of Heterocyclic Chemistry, 2009, 46(6): 1331-1334.
DOI:10.1002/jhet.223

摘要

A series of 2-amino-5-aryl-5,6-dihydropyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives were synthesized via the three-component reaction of aromatic aldehyde, 2,6-diaminopyrimidine- 4(3H)-one, and Meldrum's acid in water in the presence of triethylbenzylammonium chloride (TEBAC). This protocol has the advantages of easier work-up, milder reaction conditions, and environmentally benign procedure.