Densified Electrochemical Sensors Based on Local Redox Cycling between Vertically Separated Electrodes in Substrate Generation/Chip Collection and Extended Feedback Modes

作者：Ino Kosuke^*; Kanno Yusuke; Nishijo Taku; Komaki Hirokazu; Yamada Yuta; Yoshida Shinya; Takahashi Yasufumi; Shiku Hitoshi; Matsue Tomokazu

来源：Analytical Chemistry, 2014, 86(8): 4016-4023.

DOI：10.1021/ac500435d

A new local redox cycling-based electrochemical (LRC-EC) device integrated with many electrochemical sensors has been developed into a small chip device. The LRC-EC chip device was successfully applied for detection of alkaline phosphatase and horseradish peroxidase activity in substrate generation/chip collection (SG/CC) and extended feedback modes, respectively. The new imaging approach with extended feedback mode was particularly effective for sharpening of the image, because this mode uses feedback signals and minimizes the undesired influence of diffusion. The LRC-EC chip device is considered to be a useful tool for bioanalysis.

• 出版日期2014-4-15