Associations of Genetic Variants at Nongenic Susceptibility Loci with Breast Cancer Risk and Heterogeneity by Tumor Subtype in Southern Han Chinese Women

作者：Liang, Huiying; Li, Hong; Yang, Xuexi; Chen, Lujia; Zhu, Anna; Sun, Minying; Ye, Changsheng^*; Li, Ming^*

来源：Biomed Research International, 2016, 2016: 3065493.

DOI：10.1155/2016/3065493

• GENOME-WIDE ASSOCIATION
• CONFER SUSCEPTIBILITY
• COMMON VARIANTS
• POLYMORPHISMS
• SNPS
• 5P12

Current understanding of cancer genomes is mainly "gene centric." However, GWAS have identified some nongenic breast cancer susceptibility loci. Validation studies showed inconsistent results among different populations. To further explore this inconsistency and to investigate associations by intrinsic subtype (Luminal-A, Luminal-B, ER-&PR-&HER2+, and triple negative) among Southern Han Chinese women, we genotyped five nongenic polymorphisms (2q35: rs13387042, 5p12: rs981782 and rs4415084, and 8q24: rs1562430 and rs13281615) using MassARRAY IPLEX platform in 609 patients and 882 controls. Significant associations with breast cancer were observed for rs13387042 and rs4415084 with OR (95% CI) per-allele 1.29 (1.00-1.66) and 0.83 (0.71-0.97), respectively. In subtype specific analysis, rs13387042 (per-allele adjusted OR = 1.36, 95% CI = 1.00-1.87) and rs4415084 (per-allele adjusted OR = 0.82, 95% CI = 0.66-1.00) showed slightly significant association with Luminal-A subtype; however, only rs13387042 was associated with ER-&PR-&HER2+ tumors (per-allele adjusted OR = 1.55, 95% CI = 1.00-2.40), and none of them were linked to Luminal-B and triple negative subtype. Collectively, nongenic SNPs were heterogeneous according to the intrinsic subtype. Further studies with larger datasets along with intrinsic subtype categorization should explore and confirm the role of these variants in increasing breast cancer risk.

• 出版日期2016
• 单位广州市妇女儿童医疗中心; 南方医科大学; 广州医科大学; 广州市疾病预防控制中心