A comparative study of preparation of porous poly-L-lactide scaffolds using NaHCO(3) and NaCl as porogen materials

作者：Zhou, Zhihua^*; Liu, Xiaoping; Liu, Qingquan

来源：Journal of Macromolecular Science Part B-Physics, 2008, 47(4): 667-674.

DOI：10.1080/00222340802118804

• poly-L-lactide
• porous scaffold
• NaHCO(3)
• NaCl
• porogen

Poly-L-lactide (PLLA) scaffold materials were fabricated by using NaCO(3) and NaCl as porogens, and the influences of porogen on the properties of the scaffold were investigated. The scaffold fabricated with NaHCO(3) as porogen is more highly porous and has more macropores than that fabricated with NaCl. As a porogen, NaHCO(3) particulate is easier to leach out than NaCl, due to quickly reacting with HCl solution and producing CO(2). Distilled water soaking treatment has little effect on the viscosity average molecular mass of PLLA; however, HCl solution treatment decreases the viscosity average molecular mass of PLLA. The PLLA scaffold fabricated with NaHCO(3) has a lower compressive strength than that fabricated with NaCl.

• 出版日期2008
• 单位湖南科技大学