Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity

作者：Morillas de Laguno Pablo^*; Vargas Hitos Jose A; Rosales Castillo Antonio; Manuel Siez Uran Luis; Montalban Mendez Cristina; Gavilan Carrera Blanca; Navarro Mateos Carmen; Acosta Manzano Pedro; Delgado Fernandez Manuel; Sabio Jose M; Ortego Centeno Norberto; Callejas Rubio Jose L; Soriano Maldonado Alberto

来源：PLos One, 2018, 13(4): e0196111.

DOI：10.1371/journal.pone.0196111

Objectives
To examine the association of objectively measured physical activity (PA) intensity levels and sedentary time with arterial stiffness in women with systemic lupus erythematosus (SLE) with mild disease activity and to analyze whether participants meeting the international PA guidelines have lower arterial stiffness than those not meeting the PA guidelines.
Methods
The study comprised 47 women with SLE (average age 41.2 [standard deviation 13.9]) years, with clinical and treatment stability during the 6 months prior to the study. PA intensity levels and sedentary time were objectively measured with triaxial accelerometry. Arterial stiffness was assessed through pulse wave velocity, evaluated by Mobil-O-Graph (R) 24h pulse wave analysis monitor.
Results
The average time in moderate to vigorous PA in bouts of >= 10 consecutive minutes was 135.1 +/- 151.8 minutes per week. There was no association of PA intensity levels and sedentary time with arterial stiffness, either in crude analyses or after adjusting for potential confounders. Participants who met the international PA guidelines did not show lower pulse wave velocity than those not meeting them (b = -0.169; 95% CI: -0.480 to 0.143; P = 0.280).
Conclusions
Our results suggest that PA intensity levels and sedentary time are not associated with arterial stiffness in patients with SLE. Further analyses revealed that patients with SLE meeting international PA guidelines did not present lower arterial stiffness than those not meeting the PA guidelines. Future prospective research is needed to better understand the association of PA and sedentary time with arterial stiffness in patients with SLE.

• 出版日期2018-4-25