FACILE PREPARATION OF 1,2-DIHYDROISOQUINOLINES FROM N-BENZYLSULFONAMIDES AND BROMOACETYLENES

作者：Yamagishi Masahito; Ishii Azusa; Hata Takeshi; Urabe Hirokazu^*

来源：Heterocycles, 2015, 90(2): 847-856.

DOI：10.3987/COM-14-S(K)72

• Dihydroisoquinoline
• Isoquinoline
• Cyclization Reaction
• Haloalkyne
• Palladium Catalyst

Nucleophilic addition of N-benzylsulfonamides to 1-bromo-1-alkynes proceeded in a highly regio- and stereoselective manner to give (Z)-N-benzyl-N-(1-bromo-1-aIken-2-yl)sulfonamides. These adducts cyclized via Pd-catalyzed aromatic C-H bond activation to afford 1,2-dihydroisoquinolines in good yields.

• 出版日期2015-1-1