Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp intermedia

作者：Wei Ying; Ma Chao Mei; Chen De Yuan; Hattori Masao^*

来源：Phytochemistry, 2008, 69(9): 1875-1879.

DOI：10.1016/j.phytochem.2008.03.004

• Stauntonia obovatifoliola
• Lardizabalaceae
• triterpenoid
• 16 beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid
• 3 beta,21 beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid and 16 beta-hydroxylupane-1,20(29)-dien-3-one
• HIV-1 protease inhibitors

Three triterpenoids, 16 beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (1), 3 beta,21 beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (2) and 16 beta-hydroxylupane-1,20(29)-dien-3-one (3), along with eleven known triterpenes were isolated from stems of Stauntonia obovatifoliola Hayata subsp. intermedia (Y.C. Wu) T. Chen. Their structures were determined by analysis of HR-EI/FAB-MS and 1D and 2D NMR spectroscopic data and comparison with those in the literature. Ten of the compounds showed inhibitory activity against HIV-1 protease.

• 出版日期2008-6
• 单位贵州中医药大学