科研之友
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摘要
Aims: This is a follow-up study based on the results of our previous article, to further explore the effect of the TP53 codon 72 (rs1042522) and MDM2 SNP309 (rs2279744) polymorphisms on basal follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratios in infertility women. Materials and Methods: The distribution of two genetic polymorphisms (rs1042522 and rs2279744) and basal FSH/LH ratios were tested and analyzed in 1051 in vitro fertilization (IVF) patients at a university-affiliated hospital. Results: The TP53 codon 72 polymorphism had a significant association with the FSH/LH ratio (group I: FSH/LH <2.3 and group II: FSH/LH 2.3) (C/C vs. G/G: odds ratio [OR]=1.69, 95% confidence interval [CI]: 1.07-2.65, p=0.02; G/C vs. G/G: OR=1.86, 95% CI: 1.25-2.77, p=0.002). In a stratification analysis, C allele carriers and the C/C genotype showed a strong association with positive clinical pregnancy outcomes after IVF compared with G allele carriers and the G/G genotype in the recessive, dominant, and allelic genetic models in group I (C/C vs. G/G: OR=1.84, 95% CI: 1.25-2.69, p=0.01; C/C vs. G carrier: OR=1.52, 95% CI: 1.12-2.07, p=0.01; C carrier vs. G/G: OR=1.46, 95% CI: 1.07-2.01, p=0.02; C allele vs. G allele: OR=1.34, 95% CI: 1.11-1.62, p=0.003), no significant associations by stratification were observed for group II. No associations were found between MDM2 SNP309 and either of two groups. Conclusion: The TP53 codon 72 polymorphism is associated with FSH/LH ratios, suggesting that it is a potential predictive genetic marker of IVF outcome in patients younger than 35 years of age with baseline FSH levels below 10 IU/L and who have an FSH/LH ratio <2.3.
