A novel copper(II) mononuclear complex with the non-steroidal anti-inflammatory drug diclofenac: Structural characterization and biological activity

作者：Sayen Stephanie; Carlier Annie; Tarpin Michel; Guillon Emmanuel^*

来源：Journal of Inorganic Biochemistry, 2013, 120: 39-43.

DOI：10.1016/j.jinorgbio.2012.12.002

• Diclofenac
• Copper(II)
• Non-steroidal anti-inflammatory drug
• Biological activity
• Tumoral cell lines

A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium.

• 出版日期2013-3