NIR light-induced tumor phototherapy using photo-stable ICG delivery system based on inorganic hybrid

作者：Zhang, Huijuan; Zhang, Xiaoge; Zhu, Xing; Chen, Jianjiao; Chen, Qianqian; Zhang, Hongling; Hou, Lin; Zhang, Zhenzhong^*

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2018, 14(1): 73-84.

DOI：10.1016/j.nano.2017.08.019

• Synergistic PTT/PDT
• NIR laser responsive
• Tumor
• Ti@GO

NIR responsive inorganic hybrid (Ti@GO) was synthesized. It could absorb NIR light and convert it into local hyperthermia and ROS synchronously. Ti@GO was firstly developed as a photosensitizer and a photothermal agent to realize tumor PTT and PDT. For anti-tumor application, HA was grafted on Ti@GO simultaneously as water solubility improver and tumor targeting moiety. ICG was chosen as a model drug. Results demonstrated that HA-Ti@GO could remarkably improve ICG stability and drug accumulation in 4T1 cells, enhance tumor phototherapy efficiency and reduce light-associated side effects. HA-Ti@GO/ICG under NIR laser irradiation showed a significant decreased cell viability of 20.7 +/- 2.6% and a high DNA damage degree of 82.4 +/- 8.3%. Moreover, in vivo results showed that HA-Ti@ GO/ICG plus NIR laser achieved almost complete tumor regression on 4T1 tumor-bearing mice, with a tumor volume of 67.0 mm(3). Taken together, our study provided a promising strategy to realize synergistic PTT/PDT tumor therapy with a single NIR light.

• 出版日期2018-1
• 单位郑州大学