A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy

作者：Liao Min Tser; Tsai I Jung; Cheng Hui Teng; Lin Wei Chou; Chang Yen Wen; Lin Yi Heng; Tsau Yong Kwei^*

来源：Clinical Nephrology, 2012, 78(3): 237-240.

DOI：10.5414/CN106876

• lipoprotein glomerulopathy
• apolipoprotein E
• Apo E2 (Arg25Cys) Kyoto
• nephrotic syndrome

We report on a 12-year-old female patient with lipoprotein glomerulopathy (LPG) who was proven to be heterozygous for ApoE2 Kyoto (Arg25Cys). Her family members have the same variant but do not have obvious signs of renal function impairment. Six months of treatment with a statin caused significant clinical improvement in the lipid profile, proteinuria, and renal function. Our case suggests that administration of a statin is a potential therapeutic strategy for improving nephrotic syndrome in patients with LPG.

• 出版日期2012-9