ANTI-ALZHEIMER AND ANTI-COX-2 ACTIVITIES OF THE NEWLY SYNTHESIZED 2,3 '-BIPYRIDINE DERIVATIVES (I)

作者：Attaby Fawzy A^*; Abdel Fattah Azza M; Shaif Labeeb M; Elsayed Mohamed M

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2010, 185(1): 129-139.

DOI：10.1080/10426500902717333

• 6-(Alkylthio)-4-aryl-2, 3 '-bipyridine-5-carbonitriles
• 3-aryl-1-pyridin-3-ylprop-2-en-1-ones
• 2-cyanoethanethioamide
• 6-pyridin-3-ylthieno-[2,3-b]pyridin-3-amines
• 6-thioxo-1, 6-dihydro-2,3 '-bipyridine-5-carbonitrile

3-Aryl-1-pyridin-3-ylprop-2-en-1-ones 1a, b reacted with 2-cyanoethane-thioamide (2) to afford the corresponding 4-aryl-6-thioxo-1,6-dihydro-2,3'-bipyridine-5-carbonitriles 6a, b. The synthetic potentiality of compounds 6a, b were investigated in the present study via their reactions with several active-hydrogen containing compounds 8a-g aiming to synthesize 4-aryl6- pyridin-3-ylthieno[2,3-b] pyridin-3-amines 10a-n via 6-(alkylthio)-4-aryl-2,3'-bipyridine-5- carbonitriles 9a-n. The structures of all newly synthesized heterocyclic compounds were elucidated by considering the data of IR, (1)H NMR, and mass spectra, as well as that of elemental analyses. Anti-Alzheimer and anti-COX-2 activities for all newly synthesized heterocyclic compounds were investigated.

• 出版日期2010