Association between promoter polymorphisms of interleukin-4 gene and allergic rhinitis risk: a meta-analysis

作者：Li, Zhi-peng; Yin, Li-li; Wang, Hui; Liu, Li-si^*

来源：Journal of Huazhong University of Science and Technology-Medical Sciences, 2014, 34(3): 306-313.

DOI：10.1007/s11596-014-1275-3

• interleukin-4
• polymorphisms
• allergic rhinitis
• meta-analysis

The relationship of interleukin-4 (IL-4) C-33T and C-590T (C-589T) gene polymorphisms with allergic rhinitis was analyzed. Data about the case control studies of IL-4 gene promoter polymorphisms [C-33T and C-590T (C-589T)] and their association with allergic diseases and correlation between serum IL-4 levels and allergic rhinitis were retrieved. The Stata 12.0 statistical software was applied to analyze the correlation between IL-4 gene polymorphisms and allergic rhinitis. The meta-analysis result of TT/CC genotype of -590 (-589) polymorphism showed a significant association with allergic diseases [OR=1.93, 95% CI (1.61-2.31), P=0.00]. Meta-analysis of the TT+TC versus CC genotype of IL-4 C-33/T polymorphism revealed significant associations with allergic diseases [OR=3.23, 95% CI (1.13-9.25), P=0.03]. Meanwhile, there was a significant correlation between serum IL-4 levels and allergic rhinitis [OR=2.52, 95% CI=(1.80-3.23), P=0.00]. IL-4 gene -590 TT genotype may increase the risk of allergic rhinitis and the T allele mutation of -33 might be correlated with allergic rhinitis.

• 出版日期2014-6
• 单位华中科技大学