Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit

作者：Lamsa Karri P; Heeroma Joost H; Somogyi Peter; Rusakov Dmitri A; Kullmann Dimitri M^*

来源：Science, 2007, 315(5816): 1262-1266.

DOI：10.1126/science.1137450

Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian": It is induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.

• 出版日期2007-3-2