An efficient and promising method to prepare Ladostigil (TV3326) via asymmetric transfer hydrogenation catalyzed by Ru-Cs-DPEN in an HCOONa-H2O-surfactant system

作者：Luo, Zonghua; Qin, Fangfei; Yan, Shilei; Li, Xingshu^*

来源：Tetrahedron: Asymmetry , 2012, 23(5): 333-338.

DOI：10.1016/j.tetasy.2012.02.022

The enantiopure multi-functional anti Alzheimer's drug, Ladostigil (TV3326), was prepared by using asymmetric transfer hydrogenation (ATH) as a key step catalyzed by Ru-Cs-DPEN in an HCOONa-H2O-surfactant system. Good chemical yields with high enantiomeric excess were obtained and the catalyst could be recycled another five times.

• 出版日期2012-3-15
• 单位中山大学