Arylation of Sensitive 1-(Pyrrolidin-1-yl)-diazen-1-ium-diolate in Ionic Liquids

作者：Velazquez Carlos A; Lynn Geoffrey M; Kumar Vineet; Keefer Larry K; Malhotra Sanjay V^*

来源：Synthetic Communications, 2010, 40(9): 1322-1332.

DOI：10.1080/00397910903074079

• Diazeniumdiolate
• ionic liquid
• nitric oxide donor
• nucleophilic displacement

The purpose of this research was to investigate the stability and reactivity of 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (PYRRO/NO) in dimethylformamide (DMF, as the reference solvent) and compare them to those obtained using different ionic liquids. The results of our experiments showed that PYRRO/NO is more stable (based on reactivity) in ionic liquid [EMIM][Ms] (with reaction yields up to 52%) than in DMF, that substitution products can be separated directly and quantitatively from the ionic liquid using a single flash-column separation, and that the ionic liquids can also be recovered and reused in a second iteration of the same reaction to achieve similar yields.

• 出版日期2010