Aldolase positively regulates of the canonical Wnt signaling pathway

作者：Caspi Michal; Perry Gili; Skalka Nir; Meisel Shilhav; Firsow Anastasia; Amit Maayan; Rosin Arbesfeld Rina^*

来源：Molecular Cancer, 2014, 13(1): 164.

DOI：10.1186/1476-4598-13-164

• Wnt signaling
• Aldolase
• beta-catenin
• GSK-3 beta

The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during animal development. When over-activated, this signaling pathway is involved in cancer initiation and progression. The canonical Wnt pathway regulates the stability of beta-catenin primarily by a destruction complex containing a number of different proteins, including Glycogen synthase kinase 3 beta (GSK-3 beta) and Axin, that promote proteasomal degradation of beta-catenin. As this signaling cascade is modified by various proteins, novel screens aimed at identifying new Wnt signaling regulators were conducted in our laboratory. One of the different genes that were identified as Wnt signaling activators was Aldolase C (ALDOC). Here we report that ALDOC, Aldolase A (ALDOA) and Aldolase B (ALDOB) activate Wnt signaling in a GSK-3 beta-dependent mechanism, by disrupting the GSK-3 beta-Axin interaction and targeting Axin to the dishevelled (Dvl)-induced signalosomes that positively regulate the Wnt pathway thus placing the Aldolase proteins as novel Wnt signaling regulators.

• 出版日期2014-7-4