Akkermansia muciniphila mediates negative effects of IFN gamma on glucose metabolism

作者：Greer Renee L; Dong Xiaoxi; Moraes Ana Carolina F; Zielke Ryszard A; Fernandes Gabriel R; Peremyslova Ekaterina; Vasquez Perez Stephany; Schoenborn Alexi A; Gomes Everton P; Pereira Alexandre C; Ferreira Sandra R G; Yao Michael; Fuss Ivan J; Strober Warren; Sikora Aleksandra E; Taylor Gregory A; Gulati Ajay S; Morgun Andrey; Shulzhenko Natalia

来源：Nature Communications, 2016, 7(1): 13329.

DOI：10.1038/ncomms13329

Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFN gamma on glucose tolerance. In IFN gamma-deficient mice, A. muciniphila is significantly increased and restoration of IFN gamma levels reduces A. muciniphila abundance. We further show that IFN gamma-knockout mice whose microbiota does not contain A. muciniphila do not show improvement in glucose tolerance and adding back A. muciniphila promoted enhanced glucose tolerance. We go on to identify Irgm1 as an IFN gamma-regulated gene in the mouse ileum that controls gut A. muciniphila levels. A. muciniphila is also linked to IFN gamma-regulated gene expression in the intestine and glucose parameters in humans, suggesting that this trialogue between IFN gamma, A. muciniphila and glucose tolerance might be an evolutionally conserved mechanism regulating metabolic health in mice and humans.

• 出版日期2016-11-14