A novel synthesis of 9,13-dicis double bonds locked retinoids

作者:Qing FL*; Yue XJ
来源:Tetrahedron Letters, 1997, 38(46): 8067-8070.
DOI:10.1016/S0040-4039(97)10246-5

摘要

Synthesis of two retinoids in which the 9,13-dicis double bonds were locked in cycloalkene or thiophene was described. The key step was carbonylation of vinyl bromide 9 and 16 with carbon monoxide in the presence of Pd(PPh3)(4).