A preliminary study on cerebellar acetylcholine-mediated blood pressure regulation in young and old rats

作者：Zhu, Qingfeng; Zhou, Peiling; Wang, Shengnan; Zhang, Changzheng^*; Hua, Tianmiao

来源：Experimental Gerontology, 2015, 63: 76-80.

DOI：10.1016/j.exger.2015.02.003

• Acetylcholine
• Aging
• Blood pressure
• Cerebellar cortex

Cholinergic innervation of the cerebellar cortex can modulate cerebellar functions. However, the role of acetylcholine (ACh) in cerebellar regulation of blood pressure (BP) has not been examined. Moreover, the effect of aging on this regulation remains unexplored. In this study, carotid arterial pressure was measured in young (2 months) and old (16-20 months) rats after ACh was microinjected into the cerebellar cortex. The results showa concentration-dependent effect of ACh (30, 100, and 300mM) onmean arterial pressure (MAP), maximal decreasedMAP (MDMAP) and reactive time (all Ps < 0.05). However, responses in the old animals were significantly attenuated compared to the young (Ps < 0.05). The results indicate that cerebellar cholinergic innervation exerts depressor effects on BP regulation, and such effects undergo retrogression with aging. Further studies concerning the mechanism are needed to confirm these preliminary findings.

• 出版日期2015-3
• 单位安徽师范大学; 安庆师范大学