Azole-Resistant Aspergillus fumigatus Isolate with the TR34/L98H Mutation in Both a Fungicide-Sprayed Field and the Lung of a Hematopoietic Stem Cell Transplant Recipient with Invasive Aspergillosis

作者：Rocchi Steffi; Daguindau Etienne; Grenouillet Frederic; Deconinck Eric; Bellanger Anne Pauline; Garcia Hermoso Dea; Bretagne Stephane; Reboux Gabriel; Millon Laurence^*

来源：Journal of Clinical Microbiology, 2014, 52(5): 1724-1726.

DOI：10.1128/JCM.03182-13

A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus with the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where a non-genetically related A. fumigatus TR34/L98H isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned in agricultural areas.

• 出版日期2014-5