A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13

作者：Zhang, Lulu; Su, Jian; Shen, Fei; Ma, Zhenni; Zhao, Yiming; Xia, Lijun; Ruan, Changgeng^*

来源：Journal of Hematology & Oncology, 2017, 10(1): 42.

DOI：10.1186/s13045-017-0407-1

• von Willebrand factor
• Monoclonal antibody
• ADAMTS13

We developed a novel murine monoclonal antibody (mAb) against the C-terminal a-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and ADAMTS13 and prevented the degradation of high molecular weight VWF multimers. Importantly, SZ-179 reduced the proteolysis of VWF-R1597W mutant by rADAMTS13 dose-dependently under native conditions. Our findings reveal a potential therapeutic target for bleeding disorders.

• 出版日期2017-2-6
• 单位苏州大学