An efficient approach to 2,5-anhydro-glucitol-based 1 '-homo-N-nucleoside mimetics

作者：Bhatt Beenu; Thomson Robin J; von Itzstein Mark^*

来源：Tetrahedron Letters, 2011, 52(21): 2741-2743.

DOI：10.1016/j.tetlet.2011.03.090

• Polymerases
• Nucleosides
• 1 '-Homo-N-nucleoside
• Triazole
• Sulfation

This Letter describes an efficient synthesis of a range of 1'-homo-N-nucleoside mimetics with a series of 4-substituted 1,2,3-triazoles replacing the natural nucleobase. The synthesis of 6-O-monosulfated 1'-homo-N-nucleoside mimetic derivatives is also discussed.

• 出版日期2011-5-25