A simple and expeditious synthesis of 2,3,6-trisubstituted tetrahydropyrans through (3,5)-oxonium-ene cyclization using molecular iodine

作者：Raju N Prudhvi; Reddy B Jagan Mohan^*; Anjibabu R; Muralikrishna K; Reddy B V Subba

来源：Tetrahedron Letters, 2013, 54(28): 3639-3642.

DOI：10.1016/j.tetlet.2013.04.104

• Molecular iodine
• Oxonium-ene reaction
• Aldehydes
• Alkenols
• 3-Isopropenyl-6-methyltetrahydropyrans

A variety of aldehydes undergo a smooth coupling with 6-methylhept-5-en-2ol in the presence of molecular iodine to afford the 2,3,6-trisubstituted tetrahydropyrans in good yields through 3,5-oxonium-ene cyclization under mild and neutral conditions. This method is simple, convenient, and cost-effective.

• 出版日期2013-7-10