Fosinopril improves the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats

作者：Huang, Zhi-Bin; Deng, Chun-Yu; Lin, Mao-Huan; Yuan, Gui-Yi; Wu, Wei^*

来源：Naunyn-Schmiedebergs Archives of Pharmacology, 2014, 387(11): 1037-1044.

DOI：10.1007/s00210-014-1024-y

• Fosinopril
• Hypertrophy
• Ventricular fibrillation threshold
• Transient outward current
• Electrophysiology

This study investigated the effects of fosinopril on the electrophysiological characteristics of the left ventricular hypertrophic myocardium in spontaneously hypertensive rats (SHRs). Twenty-four 10-week-old male SHRs were divided into fosinopril and non-fosinopril groups (n = 12 each). Twelve 10-week-old Wistar-Kyoto rats were used a control group. Left ventricular mass index and ventricular fibrillation threshold (VFT) were measured after 8 weeks of fosinopril or saline treatment. L-type calcium current (I (CaL)), sodium current (I (Na)), and transient outward potassium current (I (to)) were measured in left ventricular myocytes after 8 weeks of fosinopril or saline treatment using the whole-cell patch-clamp technique. VFT was higher in the fosinopril group than in the non-fosinopril group (17.5 +/- 1.2 mA vs. 15.6 +/- 1.1 mA, P < 0.01). The density of I (CaL) was lower in the fosinopril group than in the non-fosinopril group (-7.17 +/- 0.13 pA/pF vs. -7.87 +/- 0.13 pA/pF, P < 0.05). The density of I (to) was higher in the fosinopril group than in the non-fosinopril group (14.46 +/- 0.28 pA/pF vs. 12.66 +/- 0.25 pA/pF, P < 0.05). I (to) was positively correlated with VFT (r = 0.90, P < 0.001) and was found to be associated independently with VFT (P < 0.001). Fosinopril improves the electrophysiological characteristics of the left ventricular hypertrophic myocardium in SHRs.

• 出版日期2014-11
• 单位广东省心血管病研究所; 广东省人民医院; 中山大学