Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.

作者：Naz Sadia; Farooq Umar^*; Khan Ajmal^*; Khan Haroon; Karim Nasiara; Sarwar Rizwana; Hussain Javid; Rauf Abdur

来源：Frontiers in Pharmacology, 2017, 8: 469.

DOI：10.3389/fphar.2017.00469

• benzyl derivatives
• Fragaria vesca var. nubicola
• Rosaceae
• antidepressant activity
• anti-immobility

Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, H-1-NMR, C-13-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.

• 出版日期2017-7-25