Multifunctional Nanoparticles Based on a Single-Molecule Modification for the Treatment of Drug-Resistant Cancer

作者：Wang, Dun; Tang, Jingling; Wang, Yongjun; Ramishetti, Srinivas; Fu, Qiang; Racette, Kelly; Liu, Feng^*

来源：Molecular Pharmaceutics, 2013, 10(4): 1465-1469.

DOI：10.1021/mp400022h

• multidrug resistance
• TPGS
• paclitaxel
• multifunctional nanoparticles

Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively explored for the treatment of MDR in cancer because of its ability to inhibit P-glycoprotein. Here, we have established multifunctional nanoparticles (MFNPs) using a single-molecule modification of TPGS, which can deliver a hydrophobic drug, paclitaxel (PTX), and a hydrophilic drug, fluorouracil (5-FU), and overcome MDR in cancer. Our data indicated that, when delivered into a PTX-resistant cell line using MFNPs, the combination of PTX and 5-FU was more cytotoxic than each agent individually.

• 出版日期2013-4
• 单位沈阳药科大学; 哈尔滨医科大学