A plea for risk assessment of endocrine disrupting chemicals

作者：Testai Emanuela; Galli Corrado L^*; Dekant Wolfgang; Marinovich Marina; Piersma Aldert H; Sharpe Richard M

来源：Toxicology, 2013, 314(1): 51-59.

DOI：10.1016/j.tox.2013.07.018

• Endocrine active substances (EASs)
• Endocrine disrupters (EDs)
• Monotonic dose-response
• Risk assessment
• Exposure
• Regulatory decisions

Some recent EU Regulations have focused on the potential risks posed by the presence of endocrine disrupters (ED) into the environment. However there are conflicting opinions on how to assess the risk from exposure to these molecules that can reversibly modulate hormonal activity, endocrine active substances (EAS) rather than causing irreversible damage (ED). %26lt;br%26gt;The present paper attempts to discuss that perturbation of normal endocrine homeostasis in itself may not be an adverse effect, since the endocrine system is naturally dynamic and responsive to various stimuli as part of its normal function and it is modulated according to the characteristic trend of the dose-response curve. %26lt;br%26gt;EDs should be evaluated using a weight-of-evidence (WoE) approach. If a chemical meets the criteria to be defined as an ED in experimental animals, the relevance of observed effects to the human then needs to be addressed. %26lt;br%26gt;Hazard-based risk management is therefore not justified since does not meet the criteria for a sound scientifically based assessment.

• 出版日期2013-12-6