A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer

作者：Suh Young Ah; Kim Jai Hyun; Sung Myung A; Boo Hye Jin; Yun Hye Jeong; Lee Sun Hye; Lee Hyo Jong; Min Hye Young; Suh Young Ger; Kim Kyu Won; Lee Ho Young

来源：Cancer Letters, 2013, 332(1): 102-109.

DOI：10.1016/j.canlet.2013.01.022

• Deguelin
• Breast cancer
• Apoptosis
• IGFR signaling
• IGFBP-3

In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer cells, and it significantly reduced the growth of MCF-7 cell xenograft tumors. The induction of apoptosis, inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling activation, and up-regulation of IGF-binding protein-3 (IGFBP-3) expression may be associated with deguelin-mediated antitumor effects. Our findings suggest a potential therapeutic use for deguelin in patients with triple-negative breast cancer and for those with breast cancers who are sensitive to endocrine- and HER2-targeted therapies.

• 出版日期2013-5-10