GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles

作者：Bloch Miki^*; Azem Foad; Aharonov Inbar; Ben Avi Irit; Yagil Yaron; Schreiber Shaul; Amit Ami; Weizman Abraham

来源：Fertility and Sterility, 2011, 95(1): 307-309.

DOI：10.1016/j.fertnstert.2010.07.1073

• In vitro fertilization
• GnRH agonist
• estradiol
• progesterone
• depression
• anxiety
• mood

To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters. (Fertil Steril (R) 2011; 95:307-9.

• 出版日期2011-1
• 单位上海市精神卫生中心