Base-Promoted Three-Component One-Pot Synthesis of 3-(Thiomethyl)indoles with Paraformaldehyde under Aqueous Conditions

作者：Xiao, Fuhong^*; Yuan, Shanshan; Huang, Huawen; Deng, Guo-Jun^*

来源：Synlett, 2018, 29(20): 2693-2696.

DOI：10.1055/s-0037-1611023

• metal-free
• aqueous conditions
• paraformaldehyde
• multicomponent reaction
• thiomethylation
• thiomethylindoles

An ethylenediamine- promoted three-component synthesis of 3-(thiomethyl) indoles from indoles, thiophenols, and paraformaldehyde has been developed. Water is used as the green solvent in a simple and environmentally friendly procedure. Stable and low- toxicity paraformaldehyde is used as a carbon source.

• 出版日期2018-12
• 单位湘潭大学