alpha-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

作者:Lampel Ayala; Elis Efrat; Guterman Tom; Shapira Sharon; Marco Pini; Bacharach Eran; Gazit Ehud*
来源:Chemical communications, 2015, 51(62): 12349-12352.
DOI:10.1039/c5cc01421b

摘要

The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded alpha-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

  • 出版日期2015