Discovery of HLA-B*480102 in Taiwanese

作者：Chen M J; Chu C C; Shyr M H; Lin P Y; Yang K L^*

来源：International Journal of Immunogenetics, 2008, 35(1): 15-18.

DOI：10.1111/j.1744-313X.2007.00731.x

Human leucocyte antigen (HLA)-B48, an antigen within 7C CREG (cross-reacting group) (Steiner et al., 2001) that cross-reacts frequently with HLA-B40 (i.e. HLA-B60 and -B61) group of antibodies serologically, can be found in Alaskan Natives (Leffell et al., 2002), Amerindians (Martinez-Naves et al., 1997, African Americans, Caucasians, and Oriental ethnicities (Mori et al., 1997; Schipper et al., 1997; Cao et al., 2001; Middleton et al., 2004; Hong et al., 2005; Itoh et al., 2005; Lee et al., 2005; Ogata et al., 2007). Sequencing investigations demonstrated that the common allele encoding the B48 antigen is B*4801 (Belich et al., 1992). To date, there are at least 16 WHO recognized B*48 alleles according to the most recent report from the WHO nomenclature committee (Marsh et al., 2005). Here we report a newly discovered allele B*480102, a variant of B*4801, detected in a 55-year-old Taiwanese patient of Minan origin (southern China).

• 出版日期2008-2
• 单位河北医科大学