Asperger syndrome and %26quot;non-verbal learning problems%26quot; in a longitudinal perspective: Neuropsychological and social adaptive outcome in early adult life

作者：Hagberg Bibbi S^*; Nyden Agneta; Cederlund Mats; Gillberg Christopher

来源：Psychiatry Research, 2013, 210(2): 553-558.

DOI：10.1016/j.psychres.2013.06.006

• NLD
• AS
• Neurocognitive function
• Social adaption
• Global functioning

Co-existence of Asperger syndrome (AS) and non-verbal learning disability (NLD) has been proposed based on the observation that people with AS tend to have significantly higher verbal than performance IQ (VIQ%26gt;PIQ by %26gt;= 15 points), one of the core features of NLD. In the present study we examined neuropsychological and social adaptive profiles with %26quot;non-verbal learning problems%26quot; associated with NLD in a group of individuals with AS followed from childhood into early adult life. The group was divided into three subgroups: (i) persistent NLD (P-NLD), i.e. NLD (VIQ%26gt; PIQ) both in childhood and early adulthood occasions, (ii) childhood NLD (CO-NLD), i.e. NLD (VIQ%26gt; PIQ) only at original diagnosis, or (iii) No NLD (VIQ%26gt; PIQ) ever (NO-NLD). All three subgroups were followed prospectively from childhood into adolescence and young adult life. One in four to one in five of the whole group of males with AS had P-NLD. The P-NLD subgroup had poorer neuropsychological outcome in early adult life than did those with CO-NLD and those with NO-NLD. There were no unequivocal markers in early childhood that predicted subgroup status in early adult life, but early motor delay and a history of early speech-language problems tended to be associated with P-NLD.

• 出版日期2013-12-15