科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background. To investigate a potential cardiac resynchronization method using high force density actuators and mitral regurgitation (MR) reduction devices. Methods. An 8-cm long, 0.4-mm thick, and 2-mm wide polymeric actuator strip was attached to the right ventricular (RV) pacemaker lead 4.0 cm from the edge of the leads, and 035 wire and step-up voltages (2-9 V) were given. Deformation of the pacemaker lead with polymer was studied under cine-fluoroscopy in the air and immersing it in 0.9% saline. Cantilever function was assessed by the addition of gold rings. The left ventricular (LV) lead was reinforced with dual polymer and a side branching 035 wire Y-attachment and studied. A novel nitinol-based Gore-Tex device and polymer-based technology was developed and positioned abutting the mitral valves, and was evaluated in sheep heart preparations by cine-fluoroscopy. Results. The mean deformation at 9 V for the LV leads, RV leads, and 035 wires was 3.5 +/- 0.2 mm, 1.1 +/- 0.1 mm, and 1.4 +/- 0.1 mm, respectively, and the stopping weight was 3.8 +/- 0.2 g, 3.2 +/- 0.1 g, and 3.6 +/- 0.3 g, respectively. With dual surfacing of polymer and driven by separate actuation circuits simultaneously, the stopping weight parameters increased to 4.8 +/- 0.2 g, 4.0 +/- 0.2 g, and 4.6 +/- 0.1 g, respectively (>25% each; P<.01 for all). The nitinol-based Gore-Tex device and the polymer device appeared to have reduced MR significantly from grade IV to grade I (>60% by visual quantification). Conclusion. There is potential for a novel theoretical cardiac resynchronization therapy method using polymer-based actuators and devices to control MR.
- 出版日期2013-8
- 单位河北医科大学
