Apical Rotation Assessed by Speckle-Tracking Echocardiography as an Index of Global Left Ventricular Contractility

作者：Kim Won Jang; Lee Byeong Han; Kim Yun Jeong; Kang Jee Hye; Jung Yoo Jin; Song Jong Min; Kang Duk Hyun; Song Jae Kwan^*

来源：Circulation-Cardiovascular Imaging, 2009, 2(2): 123-131.

DOI：10.1161/CIRCIMAGING.108.794719

• contractility
• ventricular rotation
• echocardioaraphy

Background-Left ventricular (LV) apical rotation and twist can be estimated noninvasively by speckle-tracking echocardiography (STE). In this study, we tested whether apical rotation is an accurate index of LV contractility.
Methods and Results-We measured LV basal and apical rotation by STE in 11 open-chest anesthetized mongrel dogs 8 different inotropic stages before and after ligation of either left anterior descending (n=6) or Circumflex coronary artery (n=5). We measured LV pressure simultaneously with a high-fidelity pressure catheter and calculated LV ejection fraction (EF) with the biplane Simpson method and 2D echocardiography. Maximal positive dP/dt (dP/dt(max)) was used as the gold standard measurement of LV contractility. We compared LV twist and apical rotation and EF against dP/dt(max) by linear mixed model. LV apical rotation and twist showed dose-dependent increases and decreases after dobutamine and esmolol infusion, respectively. However, basal rotation did not change significantly during different inotropic conditions. There was a stronger association between dP/dt(max) and LV twist (R(2)=0.747, P<0.001) and apical rotation (R(2)=0.726, P<0.001) than between dP/dt(max) and EF (R(2)=0.408, P<0.001), and this trend was more apparent with coronary ligation irrespective of the ligation site. There was also a high association between dP/dt(max) and apical rotation alone, both with (R(2)=0.805, P<0.001) and without (R(2)=0.748, P<0.001) coronary ligation. Apical rotation alone showed comparable accuracy to LV twist. Apical rotational velocity also showed a high association with dP/dt(max) (R(2)=0.669, P<0.001) and LV twist (R(2)=0.892, P<0.001).
Conclusions-Apical rotation assessed by STE is an effective noninvasive index of global LV contractility and is more closely related to dP/dt(max) than LV EF. (Circ Cardiovasc Imaging. 2009;2:123-131.)

• 出版日期2009-3