A Novel Animal Model for Hyperdynamic Airway Collapse

作者：Tsukada Hisashi; Donnell Carl R O; Garland Robert; Herth Felix; DeCamp Malcolm; Ernst Armin^*

来源：Chest, 2010, 138(6): 1322-1326.

DOI：10.1378/chest.10.0165

Objective Tracheobronchomalacia (TBM) is Increasingly recognized as a condition associated with significant pulmonary morbidity However, treatment is invasive and complex, and because there is no appropriate animal model, novel diagnostic and treatment strategies are difficult to evaluate We endeavored to develop a reliable airway model to simulate hyperdynamic airway collapse in humans
Methods Seven 20-kg male sheep were enrolled in this study Tracheomalacia was created by submucosal resection of >50% of the circumference of 10 consecutive cervical tracheal cartilage rings through a midline cervical incision A silicone stent was placed in the trachea to prevent airway collapse during recovery Tracheal collapsibility was assessed at protocol-specific time points by bronchoscopy and multidetector CT imaging while temporarily removing the stent Esophageal pressure and flow data were collected to assess flow limitation during spontaneous breathing
Results All animals tolerated the surgical procedure well and were stented without complications One sheep died at 2 weeks because of respiratory failure related to stent migration In all sheep, near-total forced inspiratory airway collapse was observed up to 3 months postprocedure Esophageal manometry demonstrated flow limitation associated with large negative pleural pressure swings during rapid spontaneous inhalation
Conclusions Hyperdynamic airway collapse can reliably be induced with this technique It may serve as a model for evaluation of novel diagnostic and therapeutic strategies for TBM CHEST 2010, 138(6) 1322-1326

• 出版日期2010-12