Neuropsychological assessments in a hyperbaric trial of post-concussive symptoms

作者：Wilson Steffanie H; Weaver Lindell K^*; Lindblad Anne S

来源：Undersea & Hyperbaric Medicine, 2016, 43(5): 585-599.

• brain concussion
• neuropsychology
• post-concussion syndrome
• methodology

Results of studies addressing the effect of mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) on symptoms and neuropsychological assessments are mixed regarding cognitive deficits in these populations. Neuropsychological assessments were compared between U.S. military service members with mTBI only (n=36) vs. those with mTBI+PTSD (n=35) from a randomized interventional study of mTBI participants with persistent post-concussive symptoms (PCS). The mTBI group endorsed worse symptoms than published norms on PCS, PTSD and pain scales (>50% abnormal on Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Civilian, McGill Pain Questionnaire-Short Form) and some quality of life domains. Worse symptom reporting was found in the mTBI+PTSD group compared to mTBI (e.g., mean NSI total score in mTBI 27.5 (SD=12.7), mTBI+PTSD 39.9 (SD=13.6), p<0.001). The mTBI+PTSD group performed worse than mTBI on the Weschler Adult Intelligence Scale digit span (mean difference-1.5, 95% Cl[-2.9,-0.1], p=0.04) and symbol search (mean difference-1.5, 95% Cl[-2.7,-0.2], p=0.03) and Grooved Pegboard (dominant hand mean difference-7.0, 95% Cl[-11.5,-2.4], p=0.003; non-dominant mean difference-9.8, 95% Cl[-14.9,-4.7], p<0.001). Differences were detected in ANAM simple reaction time (p=0.04) and mathematical processing (p=0.03) but not verbal fluency or visuospatial memory assessments. Results indicate increased symptom severity and some cognitive deficits in mTBI+PTSD compared to mTBI alone.

• 出版日期2016