No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer

作者:Stebbing Justin*; Wickenden Colin; Castellano Leandro; Sita Lumsden Ailsa; Nelson Mark; Jacob Jimmy; Naresh Kikeri; Mauri Francesco; Bower Mark
来源:AIDS, 2010, 24(8): 1221-1223.
DOI:10.1097/QAD.0b013e3283383ac9

摘要

AIDS-associated lung cancer has an increasing incidence, unaccounted for by smoking, and occurs consistently at a younger age than matched controls. We investigated whether known and new cancer-associated polyomaviruses, including the newly identified Merkel cell virus, may play a role in its etiopathogenesis. Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer.

  • 出版日期2010-5-15