科研之友
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摘要
Reports of individuality in rodent species have been a subject of debate in pharmacology and other fields. In the current study, APP(swe)+PS1/A246E bigenic mice with Alzheimer's-like pathogenesis and wild-type controls were subdivided at 3 months of age into low, intermediate, and high responders in open-field activity. The mice were then evaluated longitudinally at 3 and 9 months for object recognition. Irrespective of genotype, mice with a high level of motor activity had better scores in object recognition. However, a significant correlation was established between open-field activity measured at 3 months of age and recognition memory measured at 9 months of age in the bigenic group only. These results indicate that motor activity in young mice with amyloid neuropathology may serve as a predicting variable for cognitive dysfunction in more mature mice.
- 出版日期2015-6
