Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population

作者：Saleheen D^*; Bukhari S; Haider SR; Nazir A; Khanum S; Shafqat S; Anis K; Frossard P

来源：Stroke, 2005, 36(10): 2275-2277.

DOI：10.1161/01.STR.0000182242.59466.ee

• genetics
• risk factors
• stroke,ischemic

Background and Objectives-Identification of STRK1 locus by the deCODE group followed by the discovery of phosphodiesterase 4D ( PDE4D) gene in strong association with ischemic stroke patients has provided useful insights toward understanding the genetic etiology of the disease. In this study, we aimed at investigating the association between 3 polymorphisms of the PDE4D gene and ischemic stroke in the Pakistani population.
Methods-Three polymorphisms in PDE4D gene were analyzed in 200 patients of ischemic stroke and 250 controls of Pakistani origin using polymerase chain reaction-restriction fragment length polymorphism method. Data were coded and entered in SPSS Windows ( version 12.0). Odds ratios and 95% CIs were calculated using multivariate logistic regression analysis.
Results-Marker SNP83( rs966221) was found significantly associated with ischemic stroke on univariate and multivariate analysis ( P < 0.005; odds ratio, 1.64 [ 1.13 to 2.40]). Haplotype analysis for markers in linkage disequilibrium failed to show any association with the disease.
Conclusion-The association of PDE4D variation with ischemic stroke extends to the Pakistani population and supports a role for phosphodiesterases in stroke pathogenesis.

• 出版日期2005-10