科研之友
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摘要
A green and improved method for the synthesis of beta-amido ketones through one-pot multi-component reaction of an enolizable ketone, aryl aldehyde, acetonitrile or benzonitrile in the presence of trimethylsilyl chloride using 3-methyl-1-(4-sulfonic acid)butylimidazolium hydrogen sulfate [(CH2)(4)SO3HMIM][HSO4], a Bronsted-acidic ionic liquid, as an effective and recyclable catalyst is described. The present methodology offers several advantages such as simple procedure with an easy work-up, relatively short reaction time, and good to excellent yields.
- 出版日期2010-3
