Adenoma Incidence After Resection of Sporadic Colorectal Cancer With Microsatellite Instability

作者：Kang Ki Joo; Sinn Dong Hyun; Park Sung Hyun; Kim Jin Yong; Chang Dong Kyung; Son Hee Jung; Rhee Poong lyul; Kim Jae J; Rhee Jong Chul; Chun Ho Kyung; Kim Young Ho^*

来源：Journal of Surgical Oncology, 2010, 101(7): 577-581.

DOI：10.1002/jso.21548

• colorectal cancer
• microsatellite instability
• colorectal adenoma

Background and Objectives: Microsatellite instability (MSI) tumors that develop via the mismatch repair (MMR) gene pathway show rapid growth. It is unknown if patients with sporadic colorectal cancer (CRC) with MSI would benefit from a shorter interval between colonoscopies. The purpose of this study is to determine if there is a difference in adenoma incidence based on the presence of MST in patients with sporadic CRC.
Methods: We retrospectively reviewed the incidence of a recurring adenoma at the 1- and 3-year surveillance colonoscopies in 426 patients who had sporadic CRC after surgery
Results: The number of high MSI (MSI-H), low MSI (MSI-L), and microsatellite stable (MSS) tumors were 38 (9%), 27 (6%), and 361 (85%), respectively. After 1 year, the incidence of adenoma (13% vs. 16% for MST-L + MSS vs. MSI-H, P = 0.61) or advanced adenoma (3% vs. 8% for MSI-L + MSS vs. MSI-H, P = 0.14) did not differ based on MST status. The incidence of adenoma or advanced adenoma also did not differ based on MSI status at the 3-year surveillance colonoscopy.
Conclusions: Our study does not show recommendations for a shorter interval for subsequent colonoscopies in patients with sporadic CRC with MSI-H. Further studies on a large scale are needed. J. Surg. Oncol. 2010;101:577-581.

• 出版日期2010-6-1